From the edge of the Milky Way, a winged creature named Rokan speeds toward Earth. Superman confronts the beast and realizes it’s Rokan a beast from Krypton which was thought to be extinct and since Rokan is from Krypton she has the exact same powers as Superman. Escaping, the creature wreaks Havoc on Earth. The Super Friends attempt stop to stop Rokan by chasing her and her babies with Kryptonite.

The Wonder Twins agree to help Exxor defeat Darkon, a conquerer who has decided to take over Exxor and make its inhabitants his slaves. With the Wonder Twins captured by Darkon, Batman & Robin must free the twin heroes as the other Super Friends tackle Darkon and his troopers.

Jayna and Zan disappear while on a trip out to sea. When the SuperFriends go to find them, they are pulled into a whirlpool and are taken to a strange subterranean land at the Earth's core. There they must battle dinosaurs and tar creatures in order to save the Wonder Twins.

Sinbad and his Space Pirates come to Earth to steal its treasures. Employing a hypnotic ray, Sinbad manages to take control of Wonder Woman. Fortunately, Superman figures out a way of rescuing her and stopping Sinbad.

An alien ship uses music to hypnotize the Wonder Twins and all the rest of Earth's children. The children are taken to another planet and are forced to work as slaves. The SuperFriends must rescue the children and stop the evil alien behind the sinister plot.

Dracula returns from the grave and tries to turn everyone on the planet into vampires. As the SuperFriends rush to stop him, Superman and the Wonder Twins are turned into Vampires. The rest of the SuperFriends must find a cure for them and find a way to stop Dracula.

After an experimental Satellite from Kennedy Space Center falls back to Earth it breaks releasing deadly radioactive energy. The Super Friends then receive a distress call from the west coast saying Death Valley as been over run by giant desert beasts. Wonder Woman and the Wonder Twins stay behind to check the Justice League computer for more information while the rest of the Super Friends head to Death Valley. At Death Valley they find wreckage and a man who says giant lizards had nearly destroyed the town. As Superman continues to search for the mysterious giant beast, he stumbles upon some mutated giant earthworms that he must save some teens from. As Aquaman, Batman, and Robin fight the beast creatures that attacked them, Wonder Woman finds out what happened via the Justice League computer and heads to NASA for more information. As Wonder Woman approaches the location of the downed satellite, the radiation turns her into a giant beast. As the Wonder Twins try to stop Wonder Woman’s destruction of a military base, the radiation genetically alters them into giant beasts. Meanwhile giant earthworms are digging holes the California coast which will potentially make it sink. To save everyone the Super Friends must stop the creatures and turn them and the “Wonder” heroes back to normal.

Three Kryptonian villains from the Phantom Zone escape and expose Superman to Red Kryptonite causing him to age rapidly. The rest of the Super Friends get trapped by the villains and must now escape from the Phantom Zone. Meanwhile, the Justice League Computer tells Superman the only possible antidote for his rapid aging is Blue Kryptonite. Since Blue Kryptonite is harmful to Bizarro it may have an opposite effect on Superman since he reacts differently to Bizarro in many ways. Superman must take the Supermobile to go to the site where Krypton blew up and get the Blue Kryptonite in time and save his Super Friends to help him send the Kryptonian villains back to the Phantom Zone.

A mad scientist creates an Anti-Matter monster that is able to drain energy from power sources all over the world. When the SuperFriends try to deal with the monster, they discover to their dismay that it can drain their power as well.

The evil Tyranna tries to freeze the planet Earth. When the SuperFriends try to stop him, they are frozen. Aquaman's friends from Atlantis, however, arrive and rescue the SuperFriends. The Atlantians and the Superfriends work together to stop Tyranna and prevent a new ice age.

Evil Brain Creatures from Mars attack Earth with lightning and take over the minds of Batman and Superman. As these two Superheroes attack Earth, the rest of Superfriends must find some way to stop them and the Brain Creatures.

Alien poachers are stealing animals for use in a galactic circus. When Wonder Woman and Aquaman try to stop them, the are transformed into animals. When the poachers force these animals to fight and later capture the Wonder Twins, the rest of the SuperFriends must find a way to stop the poachers, rescue the Wonder Twins, and turn Wonder Woman and Aquaman back to normal.

The Capricorn Kid threatens to take over the planet Texicanna. Batman and Robin go to the planet and defeat the Capricorn Kid and his android cowboys. Vowing revenge, the Capricorn Kid captures the Wonder Twins and the rest of the SuperFriends setting himself up for a final confrontation with Batman.

On another planet the courage of the SuperFriends is debated the the Greek gods Aphrodire and Hera. In order to settle the debate, Zeus forces the SuperFriends to perform four dangerous tasks.

When Aquaman is exposed to a radioactive substance he is transformed into a sea creature. In order to cure him, Superman and Wonder Woman are shrunk down to microscopic size and sent within the creature to give it another dose of radiation.

Mr. Mxyzptlk is a magical imp from another dimension who comes to Earth to annoy Superman and the rest of the SuperFriends. He decides to make a movie starring the SuperFriends and forces them to fight Vikings. The SuperFriends long to be rid of the Mr. Mxyzptlk, but the only way to get rid of him is by making him say his name backward.